Publications

Lee S, Wilen CB, Orvedahl A, McCune BT, Kim K, Orchard RC, Peterson ST, Nice TJ, Baldridge MT#, Virgin HW# (2017). Norovirus cell tropism is determined by combinatorial action of a viral non-structural protein and host cytokine. Cell Host & Microbe, Cell Host Microbe. pii: S1931-3128(17)30354-2. #co-corresponding

Lee S and Baldridge MT. (2017). Interferon-lambda: A potent regulator of intestinal viral infections. Frontiers in Immunology, 8:749.

Baldridge MT*, Lee S*, Brown JJ, McAllister N, Urbanek K, Dermody TS, Nice TJ, Virgin HW. (2017). Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus. Journal of Virology, 13;91(7). *equal contribution

Josefsdottir, KS, Baldridge MT, Kadmon CS, King KY. (2017). Antibiotics impair murine hematopoiesis by depleting intestinal microbiota. Blood, 129(6):729-739.

Baldridge MT, Turula H, Wobus CE. (2016). Norovirus regulation by host and microbe. Trends in Molecular Medicine, 22(12):1047-1059.

Orchard RC*, Wilen CB*, Doench JG, Baldridge MT, McCune BT, Lee YCJ, Lee S, Pruett-Miller S, Nelson CA, Fremont DH, Virgin HW. (2016). Discovery of a proteinaceous cellular receptor for a norovirus. Science, 353(6302):933-6. *equal contribution

Liu T, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DPB, Xavier RJ, Stappenbeck TS, Salzman NH. (2016). Paneth cell defects in Crohn’s disease patients promote dysbiosis. JCI Insight, 1(8):e86907.

Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. (2016). Altered virome and bacterial microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe, 19(3):311-22.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon ACM, Zhang H, Randolph GJ, Artyomov MN, Virgin HW (2016). Homeostatic control of innate lung inflammation by Vici Syndrome gene Epg5 and additional autophagy genes promotes influenza pathogenesis. Cell Host & Microbe, 19(1):102–113.

Moon C*, Baldridge MT*, Wallace MA, Burnham CD, Virgin HW, Stappenbeck TS. (2015). Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation. Nature, 521(7550):90-3. *equal contribution

Baldridge MT, Nice TJ, McCune BT, Yokoyama C, Kambal A, Wheadon M, Lazear HM, Diamond MS, Ivanova Y, Artyomov M, Virgin HW. (2015). Commensal microbes and interferon-λ determine persistence off enteric murine norovirus infection. Science, 347(6219):266-9.

Nice TJ, Baldridge MT, McCune BT, Norman JM, Lazear HM, Artyomov M, Diamond MS, Virgin HW. (2015). Interferon λ cures persistent murine norovirus infection in the absence of adaptive immunity. Science, 347(6219):269-73.

Norman JM*, Handley SA*, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW. (2015). Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease. Cell, 160(3):447-60. *equal contribution

Nelson AM, Elftman MD, Pinto AK, Baldridge M, Hooper P, Kuczynski J, Petrosino JF, Young VB and Wobus CE. (2013). Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota. Microbiome; 1:7.

Baldridge MT, King KY, Goodell MA. (2011). Inflammatory signals regulate hematopoietic stem cells. Trends in Immunology; 32(2):57-65.

King KY*, Baldridge MT*, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, and Goodell MA. (2011). Irgm1 protects hematopoietic stem cells by negative regulation of interferon signaling. Blood, 118(6):1525-33. *equal contribution

Baldridge MT*, King KY*, Boles NC, Weksberg DC, and Goodell MA. Quiescent hematopoietic stem cells are activated by IFN-gamma in response to chronic infection. (2010). Nature, 465: 793-797. *equal contribution