Publications

Makimaa H, Ingle H, Baldridge MT (2020). Enteric Viral Co-Infections: Pathogenesis and Perspective. Viruses. 12(8):904.

Furlong K, Biering S, Choi J, Wilen CB, Orchard RC, Wobus CE, Fremont D, Baldridge MT, Randall G, and Hwang S (2020). CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner. Journal of Virology. JVI.00837-20.

Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT#, Wilen CB# (2020). CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathogens. 16(4):e1008242. #co-corresponding

Lee AG, Scott JM, Fabbrizi MR, Jiang X, Sojka DK, Miller MJ, Baldridge MT, Yokoyama WM, Shin H (2020). T cell response kinetics determines neuroinfection outcomes during murine HSV infection. JCI Insight. 5(5). pii: 134258.

Wang YT, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL, Virgin HW (2020). Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nature Microbiology. doi: 10.1038/s41564-019-0633-0.

Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT#, Karst SM# (2020). The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nature Microbiology. 5(1):84-92. #co-corresponding

Lee S, Baldridge MT (2019). Viruses RIG up intestinal immunity. Nature Immunology. 20(12):1563-1564.

Shi Z, Zou J, Zhang Z, Zhao X, Noriega J, Zhang B, Zhao C, Ingle H, Bittinger K, Mattei LM, Pruijssers AJ, Plemper RK, Nice TJ, Baldridge MT, Dermody TS, Chassaing B, and Gewirtz AT (2019). Segmented filamentous bacteria prevent and cure rotavirus infection. Cell. 179(3):644-658

Hassan E, Baldridge MT (2019). Norovirus encounters in the gut: multifaceted interactions and disease outcomes. Mucosal Immunology, 12(6): 1259-1267.

Peterson ST*, Kennedy E*, Brigleb P, Taylor G, Urbanek K, Bricker T, Lee S, Shin H, Dermody T, Boon ACM, and Baldridge MT (2019). Disruption of type III interferon genes Ifnl2 and Ifnl3 recapitulates loss of the type III IFN receptor in the mucosal antiviral response. Journal of Virology, 93(22). *equal contribution

Lawrence D, Baldridge MT#, Handley SA# (2019). Phages and Human Health: More Than Idle Hitchhikers. Viruses, 11(7). pii: E587. #co-corresponding

Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ (2019). A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus-68. Journal of Virology, 93(19).

Wilke G, Funkhouser-Jones LJ, Wang Y, Ravindran S, Wang Q, Beatty WL, Baldridge MT, VanDussen KL, Shen B, Kuhlenschmidt MS, Kuhlenschmidt TB, Witola WH, Stappenbeck TS, Sibley LD (2019). A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host & Microbe, 26(1):123-134.

Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL, Orchard RC, McCune BT, Kim K, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW (2019). A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host & Microbe, 25(6):845-857.

Walker FC, Baldridge MT (2019). Interactions between noroviruses, the host, and the microbiota. Current Opinion in Virology, 37:1-9.

Ingle H*, Lee S*, Ai T, Orvedahl A, Rodgers R, Zhao G, Sullender M, Peterson ST, Locke M, Liu TC, Yokoyama CC, Sharp B, Schultz-Cherry S, Miner JJ, Baldridge MT (2019). Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Nature Microbiology, 4(7):1120-1128. *equal contribution

Bennion BG*, Ingle H*, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT#, Miner JJ(2018). A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice. Journal of Virology, 93(4). *equal contribution, #co-corresponding

Kennedy EA, King KY, Baldridge MT (2018). Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria. Frontiers in Physiology, 9:1534.

MacDuff DA*, Baldridge MT*, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW (2018). HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. Journal of Virology, 92(23). *equal contribution

Sullender ME, Baldridge MT (2018). Norovirus interactions with the commensal microbiota. PLoS Pathogens14(9):e1007183.

Yan H, Baldridge MT, King KY (2018). Hematopoiesis and the bacterial microbiomeBlood,132(6):559-564.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr., McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW (2018). Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science, 360(6385):204-208.

Ingle H*, Peterson ST*, Baldridge MT (2018). Distinct effects of type I and III interferons on enteric virusesViruses, 10(1), 46. *equal contribution

Lee S, Wilen CB, Orvedahl A, McCune BT, Kim K, Orchard RC, Peterson ST, Nice TJ, Baldridge MT#, Virgin HW# (2017). Norovirus cell tropism is determined by combinatorial action of a viral non-structural protein and host cytokine. Cell Host & Microbe, 22(4):449-459. #co-corresponding

Lee S and Baldridge MT. (2017). Interferon-lambda: A potent regulator of intestinal viral infections. Frontiers in Immunology, 8:749.

Baldridge MT*, Lee S*, Brown JJ, McAllister N, Urbanek K, Dermody TS, Nice TJ, Virgin HW. (2017). Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus. Journal of Virology, 13;91(7). *equal contribution

Josefsdottir, KS, Baldridge MT, Kadmon CS, King KY. (2017). Antibiotics impair murine hematopoiesis by depleting intestinal microbiota. Blood, 129(6):729-739.

Baldridge MT, Turula H, Wobus CE. (2016). Norovirus regulation by host and microbe. Trends in Molecular Medicine, 22(12):1047-1059.

Orchard RC*, Wilen CB*, Doench JG, Baldridge MT, McCune BT, Lee YCJ, Lee S, Pruett-Miller S, Nelson CA, Fremont DH, Virgin HW. (2016). Discovery of a proteinaceous cellular receptor for a norovirus. Science, 353(6302):933-6. *equal contribution

Liu T, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DPB, Xavier RJ, Stappenbeck TS, Salzman NH. (2016). Paneth cell defects in Crohn’s disease patients promote dysbiosis. JCI Insight, 1(8):e86907.

Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. (2016). Altered virome and bacterial microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe, 19(3):311-22.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon ACM, Zhang H, Randolph GJ, Artyomov MN, Virgin HW (2016). Homeostatic control of innate lung inflammation by Vici Syndrome gene Epg5 and additional autophagy genes promotes influenza pathogenesis. Cell Host & Microbe, 19(1):102–113.

Moon C*, Baldridge MT*, Wallace MA, Burnham CD, Virgin HW, Stappenbeck TS. (2015). Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation. Nature, 521(7550):90-3. *equal contribution

Baldridge MT, Nice TJ, McCune BT, Yokoyama C, Kambal A, Wheadon M, Lazear HM, Diamond MS, Ivanova Y, Artyomov M, Virgin HW. (2015). Commensal microbes and interferon-λ determine persistence off enteric murine norovirus infection. Science, 347(6219):266-9.

Nice TJ, Baldridge MT, McCune BT, Norman JM, Lazear HM, Artyomov M, Diamond MS, Virgin HW. (2015). Interferon λ cures persistent murine norovirus infection in the absence of adaptive immunity. Science, 347(6219):269-73.

Norman JM*, Handley SA*, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW. (2015). Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease. Cell, 160(3):447-60. *equal contribution

Nelson AM, Elftman MD, Pinto AK, Baldridge M, Hooper P, Kuczynski J, Petrosino JF, Young VB and Wobus CE. (2013). Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota. Microbiome; 1:7.

Baldridge MT, King KY, Goodell MA. (2011). Inflammatory signals regulate hematopoietic stem cells. Trends in Immunology; 32(2):57-65.

King KY*, Baldridge MT*, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, and Goodell MA. (2011). Irgm1 protects hematopoietic stem cells by negative regulation of interferon signaling. Blood, 118(6):1525-33. *equal contribution

Baldridge MT*, King KY*, Boles NC, Weksberg DC, and Goodell MA. Quiescent hematopoietic stem cells are activated by IFN-gamma in response to chronic infection. (2010). Nature, 465: 793-797. *equal contribution